Inhibition of phosphatidylinositol kinase by toyocamycin.
نویسندگان
چکیده
We have screened toyocamycin as an inhibitor of phosphatidylinositol kinase. It inhibited the enzyme of A431 cell membrane with an IC50 of 3.3 micrograms/ml. Adenosine and formycin A also inhibited the enzyme, but other 6 related nucleosides did not. Although orobol and 2,3-dihydroxybenzaldehyde that inhibit phosphatidylinositol kinase inhibited in situ phosphatidylinositol turnover, toyocamycin did not.
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عنوان ژورنال:
- The Journal of antibiotics
دوره 43 12 شماره
صفحات -
تاریخ انتشار 1990